Antiglomerular Basement Membrane Disease
نویسندگان
چکیده
منابع مشابه
The antiglomerular basement membrane disease: treatments and outcomes
Introduction Antiglomerular basement membrane (anti-GBM) disease is a rare autoimmune disorder characterized by rapidly progressive glomerulonephritis (RPGN) with diffuse crescentic formation on renal biopsy, and it is a well-characterized cause of glomerulonephritis. Although the effectiveness of treatment using therapeutic plasma exchange combined with immunosuppressive agents to improve rena...
متن کاملAtypical Antiglomerular Basement Membrane Disease With IgG1-κ Staining
INTRODUCTION A ntiglomerular basement membrane (GBM) disease is an autoimmune disease that classically presents as a rapidly progressive crescentic glomerulonephritis, with or without pulmonary hemorrhage, and typically does not relapse. The anti-GBM autoantibodies, typically polyclonal IgG1 and IgG4, bind to the noncollagenous 1 domain of the alpha-3 chain of type IV collagen that is present o...
متن کاملA Case of Alport Syndrome with Posttransplant Antiglomerular Basement Membrane Disease despite Negative Antiglomerular Basement Membrane Antibodies by EIA Treated with Plasmapheresis and Intravenous Immunoglobulin
Posttransplant antiglomerular basement membrane (anti-GBM) disease occurs in approximately 5% of Alport patients and usually ends in irreversible graft failure. Recent research has focused on characterizing the structure of the anti-GBM alloepitope. Here we present a case of a 22-year-old male with end-stage renal disease secondary to Alport syndrome, with a previously failed renal allograft, w...
متن کاملTransformation of membranous nephropathy into antiglomerular-basement membrane glomerluonephritis
Transformation of membranous nephropathy into antiglomerular-basement membrane glomerluonephritis Sir, Further to the recently published case of membranous nephropathy with superimposed anti-neutrophil cyto-plasmic antibody (ANCA)-associated vasculitis [1], we report a case of membranous nephropathy (MN) with crescentic transformation secondary to antiglomerular basement membrane (antiGBM) anti...
متن کاملAntiglomerular basement membrane glomerulonephritis following D-penicillamine-associated nephrotic syndrome.
Antiglomerular basement membrane (anti-GBM) glomerulonephritis (GN) is rare and is characterized by rapidly progressive GN with IgG linear deposits along the GBM in immunofluorescence study and circulating anti-GBM antibodies. This form of GN usually occurs without previous renal disease, but some cases of membranous GN have been reported with secondary development of antiGBM disease [1,2]. Adm...
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ژورنال
عنوان ژورنال: Seminars in Respiratory and Critical Care Medicine
سال: 2018
ISSN: 1069-3424,1098-9048
DOI: 10.1055/s-0038-1669413